| Date | | | |
| 1525 | | A plague throughout Ireland, and more particularly in Dublin, caused by a very hot summer and wet autumn. Con O'Neal and Hugh Roe O'Donncl came to Dublin to settle their disputes with the lord deputy, the Earl of Kildare, and the Council, but returned without coming to an amicable agreement. | |
| 1531 | | A great riot in High-street between the soldiers and city apprentices. | |
| 1534 | | Rebellion of Thomas Fitzgerald, son to the Earl of Kildare, commonly called the Silken Knight, who invested the city, and set up a battery against the Castle, but without success. Archbishop Allen, in endeavouring to escape into England, was taken at Artane, and put to death by the insurgents. The dissolved monastery of All Hallows granted to the citizens for their services and losses. An earthquake felt in Dublin. | |
| 1535 | | George Browne, archbishop of Dublin, embraces the Reformation. | |
| 1536 | | St. Patrick's staff, which had been brought from Armagh, and deposited in Christ's Church, burnt. | |
| 1538 | | The sweating sickness carries off great numbers of the citizens. Plays acted at Hoggin's green now College green before the Earl of Ossory, lord justice. | |
| 1539 | | The Lord Deputy Grey, with the assistance of the citizens of Dublin, defeats O'Neill at Bellabroa. | |
| 1540 | | Silver testoons, two-pennies, and pennies, coined in Dublin. | |
| 1541 | | HenryVIII proclaimed king of Ireland instead of lord as before. General pardon on the proclamation of his new title. The Priory of Christ Church converted into a deanery and Chapter, and the Priory of Kilmainham extinguished. | |
| 1543 | | O'Donnel and his two brothers taken prisoners and confined when attending a council in Dublin, but after some time liberated. | |